![]() ![]() Carcinoid tumor of the common bile duct: A rare complication of von Hippel-Lindau syndrome. ![]() Carcinoid tumor of the common bile duct: Report of a case and a review of the literature. Caglikulekci M, Dirlik M, Aydin O, Ozer C, Colak T, Dag A, Canbaz H, Aydin S. Malignant carcinoid tumor of the common bile duct: Report of a case. Non functioning well-differentiated neuroendocrine tumor of the extrahepatic bile duct: An unusual suspect? Hepatobiliary Pancreat Dis Int 2007 6:549-52. Sethi H, Madanur M, Srinivasan P, Portmann B, Heaton N, Rela M. Hepatobiliopancreatic Surgery and Transplantation Unitĭepartment of General Surgery and Digestive Diseases Miguel Ángel Gómez-Bravo and Javier Padillo-Ruiz Luis Miguel Marín-Gómez, Gonzalo Suárez-Artacho, Juan Serrano-Díez-Canedo, José Aurelio Navas-Cuéllar, José María Álamo-Martínez, Carmen Bernal-Bellido, Beatriz Martín-Pérez, Large tumors that infiltrate the proximal pancreas may require a cephalic duodenopancreatectomy. Complete resection of the extrahepatic bile ducts with a biliodigestive reconstruction (Roux-en-Y hepaticojejunostomy) with portal lymphadenectomy must be performed, that achieves a long-term high survival rate. Radical resection of the tumor is the main prognostic factor in patients with biliary NETs. The definitive diagnosis is established by histopathological and immunohistochemical analysis of the surgical specimen (3,5). ![]() Differential diagnosis must be established with other hepatic and biliary tumors. The submucosal location of these tumors determines a large number of false negative results on brush biopsy, making it difficult to achieve a correct preoperative diagnosis. They are more prevalent in women, during the fifth decade of life (2,4).Īlthough NETs may be hormonally active, most cases are not-functioning and the symptoms result from bile duct obstruction, like itching or biliary colic, which is difficult to be identified on imaging studies. The most common anatomical locations are the common bile duct (58 %), perihiliar (28 %), cyst duct (11 %) and common hepatic duct (3 %). 1D).īiliary neuroendocrine tumors (NETs) are extremely rare, accounting for 0.1 %-2 % of all gastrointestinal neuroendocrine tumors (1). Typical immunohistochemical properties were positive: chromogranin A +, synaptophysin+, CD56 +, CK AE1/AE3 + ( Fig. #GPT WEBSITE PHP SCRIPT RARITY FREE#Histological study informed of a well diferentiated neuroendocrine carcinoma of the common bile duct, TNE G2 (mitotic index: 3x10 HPF, Ki-67 3 %), with free margins and no nodal infiltration. The patient had a favorable postoperative recovery and was discharged without complications. 1C), with a lymphadenectomy and a Roux-en-Y hepaticojejunostomy. A resection of the bile duct, from the upper pancreatic edge to the bile ducts confluence at the hepatic hilium, was performed ( Fig. 1B), with no hepatic infiltration (proved with intraoperative ultrasound). The patient underwent surgical exploration, finding a large tumor solely dependent of the common bile duct ( Fig. 1A), which showed an apparently benign mass compressing the common bile duct and hampering bile flow without causing a complete obstruction of the bile duct. The screening was completed with a computed tomography scan (CT) and a magnetic resonance imaging (MRI) ( Fig. An abdominal ultrasound was performed showing a nodular image of 4x3 cm adjacent to the hepatic hilium that compressed the common bile duct at this level and caused dilatation of the intrahepatic bile ducts. Coagulation tests, blood count and tumor markers (alpha-fetoprotein 1.5 ng / ml) were within normal range. Blood tests revealed an elevation of liver enzymes (GOT 118 UI/l, GPT 215 UI/l, GGT 187 UI/l, and alkaline phosphatase 214 UI/l) without any other alteration in biochemical parameters. On examination the patient presented good general condition, with slight muco-cutaneous pallor, no jaundice, and mild discomfort in lower abdomen. Resección vía biliar.Ī 37-year-old female patient was admitted to the Emergency department complaining of itching, vomits, diarrhea, and abdominal discomfort for months. Neuroendocrine carcinoma of the common bile ductĬarcinoma neuroendocrino de vía biliar extrahepática ![]()
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